People have different feeling skills of the bitterness of compound phenylthiocarbamide (PTC). This trait has been shown to correlate with a number of dietary preferences and thus may have important implications for human health. There are two types of phenotypes in different ethno groups and populations according to this feature: PTC tester and PTC non-tester. Both phenotypes, besides some rare exceptions, are fixed in almost every population. We have studied the phenotypic variants of feeling the PTC bitterness spread in Georgian ethno group for the first time. Basing on the conducted experiments, about ¾ of the investigated population turned out to be sensitive towards PTC, and ¼ of the population – insensitive. We have analyzed the phenotypic structure of PTC feeling in the people who smoke in the population. The majority of the smokers (70%) turned out to be PTC non-tester and only 30% - PTC tester. It is important to study the phenotypic variants of feelings coded with TAS2R38 gene in the point of view of both – genetic structure of the population and bio-ecology in order to plan different kinds of preventive measures.
Published in |
American Journal of Environmental Protection (Volume 4, Issue 3-1)
This article belongs to the Special Issue Applied Ecology: Problems, Innovations |
DOI | 10.11648/j.ajep.s.2015040301.37 |
Page(s) | 175-179 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
PTC, Phenotype, Tester, Non-Tester
[1] | Kim UK, Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clin Genet. 2005 Apr;67(4), 275-280. |
[2] | Bibiana Garcia-Bailo, Clare Toguri, Karen M. Eny, and Ahmed El-Sohemy. Genetic Variation in Taste and Its Influence on Food Selection. OMICS A Journal of Integrative Biology 2009, v. 13(1), pp.69-80 |
[3] | Drewnowski A., Rock CL.The influence of genetic taste markers on food acceptance. Am J Clin Nutr 1995, v.62, pp. 506–511 |
[4] | O.V. Filiptsova, I.A. Timoshyna, Yu.N. Kobets, M.N. Kobets, I.S. Burlaka, I.A. Hurko. The population structure of Ukraine in relation to the phenylthiocarbamide sensitivity. Egyp MedHumGenet.. http://dx.doi.org/10.1016 /j.ejmhg. 2014.12.003. Published online January, 2015 |
[5] | Facchini F., Pettener D., Rimondi A., Sichimbaeva K., Riva P., Salvi P., Pretolani E., Fiori G. Taste sensitivity to PTC and thyroid function (FT4 and TSH) in high- and low-altitude Kirghiz populations in the Pamir Hum Biol. 1994, v. 69(1), 97-106 |
[6] | Cannon DS, Baker TB, Piper ME, Scholand MB, Lawrence DL, Drayna DT, McMahon WM, Villegas GM, Caton TC, Coon H, Leppert MF. Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking. Nicotine Tob Res. 2005, v.7(6), 853-858 |
[7] | Saraswathi YS, Mohsen Najafi, Vineeth VS, Kavitha P, Suttur S. Malini Association of phenylthiocarbamide taste blindness trait with early onset of childhood obesity in Mysore. Journal of Paramedical Sciences. 2011, vol.2 (4), 6-11 |
[8] | Kim U, Wooding S, Ricci D, Jorde LB, Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat. 2005, v. 26(3), 199-204 |
[9] | Campa D, Rango F, Carrai M, Crocco, Montesanto A, CanzianF, Rose G, Rizzato C, Giuseppe P, Roberto Barale R. itter Taste Receptor Polymorphisms and Human Aging. PLoS One. 2012; 7(11): e45232.Published online November, 2012 |
[10] | Shivaprasad H.S., Chaithra P.T., Kavitha P., Suttur S. Malini Role of phenylthiocarbamide as a genetic marker in predicting the predisposition of disease traits in Humans. J Nat Sci Biol Med. 2012, v. 3(1), 43–47 |
APA Style
Rusudan Khukhunaishvili, Marina Koridze, Marina Nagervadze, Ciuri Khizrevanidze, Shorena Gabaidze. (2015). Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance. American Journal of Environmental Protection, 4(3-1), 175-179. https://doi.org/10.11648/j.ajep.s.2015040301.37
ACS Style
Rusudan Khukhunaishvili; Marina Koridze; Marina Nagervadze; Ciuri Khizrevanidze; Shorena Gabaidze. Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance. Am. J. Environ. Prot. 2015, 4(3-1), 175-179. doi: 10.11648/j.ajep.s.2015040301.37
AMA Style
Rusudan Khukhunaishvili, Marina Koridze, Marina Nagervadze, Ciuri Khizrevanidze, Shorena Gabaidze. Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance. Am J Environ Prot. 2015;4(3-1):175-179. doi: 10.11648/j.ajep.s.2015040301.37
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TY - JOUR T1 - Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance AU - Rusudan Khukhunaishvili AU - Marina Koridze AU - Marina Nagervadze AU - Ciuri Khizrevanidze AU - Shorena Gabaidze Y1 - 2015/06/25 PY - 2015 N1 - https://doi.org/10.11648/j.ajep.s.2015040301.37 DO - 10.11648/j.ajep.s.2015040301.37 T2 - American Journal of Environmental Protection JF - American Journal of Environmental Protection JO - American Journal of Environmental Protection SP - 175 EP - 179 PB - Science Publishing Group SN - 2328-5699 UR - https://doi.org/10.11648/j.ajep.s.2015040301.37 AB - People have different feeling skills of the bitterness of compound phenylthiocarbamide (PTC). This trait has been shown to correlate with a number of dietary preferences and thus may have important implications for human health. There are two types of phenotypes in different ethno groups and populations according to this feature: PTC tester and PTC non-tester. Both phenotypes, besides some rare exceptions, are fixed in almost every population. We have studied the phenotypic variants of feeling the PTC bitterness spread in Georgian ethno group for the first time. Basing on the conducted experiments, about ¾ of the investigated population turned out to be sensitive towards PTC, and ¼ of the population – insensitive. We have analyzed the phenotypic structure of PTC feeling in the people who smoke in the population. The majority of the smokers (70%) turned out to be PTC non-tester and only 30% - PTC tester. It is important to study the phenotypic variants of feelings coded with TAS2R38 gene in the point of view of both – genetic structure of the population and bio-ecology in order to plan different kinds of preventive measures. VL - 4 IS - 3-1 ER -