This study evaluated the effect of methanolic, ethanolic, aqueous and crude extracts of Gongronema latifolium leaves on some nephrotoxic and hepatotoxic parameters in streptozocin induced diabetic rats. Thirty albino rats divided into six experimental groups were used. Two groups served as control were fed normal saline and glibenclamide. Four groups were fed methanolic, ethanolic, crude and aqueous extracts of Gongronema latifolium leaves respectively. Treatment lasted four 14 days after which the rats were sacrificed and blood collected for biochemical evaluation. The results showed that treatment with all the various extracts of Gongronema latifolium leave did not cause any significant increase in the nephrotoxic and hepatotoxic parameters. Treatment with methanolic extract caused a significant decrease in the serum glutamate pyruvate transaminase activity (P<0.001). The histological analysis revealed a recovery from inflammatory phase of the cells of the kidney and liver from the toxic effect of the streptozocin.
| Published in | American Journal of Health Research (Volume 4, Issue 3) |
| DOI | 10.11648/j.ajhr.20160403.15 |
| Page(s) | 62-69 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Hepatoxicity, Nephrotoxicity, Gongronema latifolium, Diabetes, Plant Extracts, Phytochemicals
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APA Style
Brown Holy, Tamunoemine Davies, Thompson N. Imomoemi. (2016). Hepato-Renal Toxicity of Gongronema latifolium Extracts on Streptozocin Induced Diabetes in Rats. American Journal of Health Research, 4(3), 62-69. https://doi.org/10.11648/j.ajhr.20160403.15
ACS Style
Brown Holy; Tamunoemine Davies; Thompson N. Imomoemi. Hepato-Renal Toxicity of Gongronema latifolium Extracts on Streptozocin Induced Diabetes in Rats. Am. J. Health Res. 2016, 4(3), 62-69. doi: 10.11648/j.ajhr.20160403.15
AMA Style
Brown Holy, Tamunoemine Davies, Thompson N. Imomoemi. Hepato-Renal Toxicity of Gongronema latifolium Extracts on Streptozocin Induced Diabetes in Rats. Am J Health Res. 2016;4(3):62-69. doi: 10.11648/j.ajhr.20160403.15
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Download@article{10.11648/j.ajhr.20160403.15,
author = {Brown Holy and Tamunoemine Davies and Thompson N. Imomoemi},
title = {Hepato-Renal Toxicity of Gongronema latifolium Extracts on Streptozocin Induced Diabetes in Rats},
journal = {American Journal of Health Research},
volume = {4},
number = {3},
pages = {62-69},
doi = {10.11648/j.ajhr.20160403.15},
url = {https://doi.org/10.11648/j.ajhr.20160403.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20160403.15},
abstract = {This study evaluated the effect of methanolic, ethanolic, aqueous and crude extracts of Gongronema latifolium leaves on some nephrotoxic and hepatotoxic parameters in streptozocin induced diabetic rats. Thirty albino rats divided into six experimental groups were used. Two groups served as control were fed normal saline and glibenclamide. Four groups were fed methanolic, ethanolic, crude and aqueous extracts of Gongronema latifolium leaves respectively. Treatment lasted four 14 days after which the rats were sacrificed and blood collected for biochemical evaluation. The results showed that treatment with all the various extracts of Gongronema latifolium leave did not cause any significant increase in the nephrotoxic and hepatotoxic parameters. Treatment with methanolic extract caused a significant decrease in the serum glutamate pyruvate transaminase activity (P<0.001). The histological analysis revealed a recovery from inflammatory phase of the cells of the kidney and liver from the toxic effect of the streptozocin.},
year = {2016}
}
TY - JOUR T1 - Hepato-Renal Toxicity of Gongronema latifolium Extracts on Streptozocin Induced Diabetes in Rats AU - Brown Holy AU - Tamunoemine Davies AU - Thompson N. Imomoemi Y1 - 2016/05/14 PY - 2016 N1 - https://doi.org/10.11648/j.ajhr.20160403.15 DO - 10.11648/j.ajhr.20160403.15 T2 - American Journal of Health Research JF - American Journal of Health Research JO - American Journal of Health Research SP - 62 EP - 69 PB - Science Publishing Group SN - 2330-8796 UR - https://doi.org/10.11648/j.ajhr.20160403.15 AB - This study evaluated the effect of methanolic, ethanolic, aqueous and crude extracts of Gongronema latifolium leaves on some nephrotoxic and hepatotoxic parameters in streptozocin induced diabetic rats. Thirty albino rats divided into six experimental groups were used. Two groups served as control were fed normal saline and glibenclamide. Four groups were fed methanolic, ethanolic, crude and aqueous extracts of Gongronema latifolium leaves respectively. Treatment lasted four 14 days after which the rats were sacrificed and blood collected for biochemical evaluation. The results showed that treatment with all the various extracts of Gongronema latifolium leave did not cause any significant increase in the nephrotoxic and hepatotoxic parameters. Treatment with methanolic extract caused a significant decrease in the serum glutamate pyruvate transaminase activity (P<0.001). The histological analysis revealed a recovery from inflammatory phase of the cells of the kidney and liver from the toxic effect of the streptozocin. VL - 4 IS - 3 ER -
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