Adrenomedullin (AM) is a novel hypotensive peptide that also exerts powerful anti-inflammatory effects. We recently showed that AM significantly reduces the clinical severity of acetic acid-induced colitis, an experimental model of inflammatory bowel disease (IBD) in rats. In the present study, we examined the effect of AM in two alternative rat models of IBD. We found that 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced megacolon development in the saline-treated group, but AM treatment reduced the macroscopic damage caused by TNBS. In the dextran sulfate sodium (DSS) model, treatment with AM reduced diarrhea and bloody stool scores, but did not reduce body weight. Histological analysis revealed that in both the TNBS and DSS models, colon inflammation was much more severe in the saline-treated group than in the AM-treated group. These findings indicate that the anti-inflammatory properties of AM make it an effective therapeutic agent for the treatment of IBD in rats.
| Published in |
American Journal of Life Sciences (Volume 3, Issue 3-2)
This article belongs to the Special Issue Biology and Medicine of Peptide and Steroid Hormones |
| DOI | 10.11648/j.ajls.s.2015030302.17 |
| Page(s) | 39-42 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Adrenomedullin, Inflammatory Bowel Disease, TNBS, DSS
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APA Style
Sayaka Nagata, Tomomi Hikosaka, Kazuo Kitamura. (2015). Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease. American Journal of Life Sciences, 3(3-2), 39-42. https://doi.org/10.11648/j.ajls.s.2015030302.17
ACS Style
Sayaka Nagata; Tomomi Hikosaka; Kazuo Kitamura. Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease. Am. J. Life Sci. 2015, 3(3-2), 39-42. doi: 10.11648/j.ajls.s.2015030302.17
AMA Style
Sayaka Nagata, Tomomi Hikosaka, Kazuo Kitamura. Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease. Am J Life Sci. 2015;3(3-2):39-42. doi: 10.11648/j.ajls.s.2015030302.17
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Download@article{10.11648/j.ajls.s.2015030302.17,
author = {Sayaka Nagata and Tomomi Hikosaka and Kazuo Kitamura},
title = {Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease},
journal = {American Journal of Life Sciences},
volume = {3},
number = {3-2},
pages = {39-42},
doi = {10.11648/j.ajls.s.2015030302.17},
url = {https://doi.org/10.11648/j.ajls.s.2015030302.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.s.2015030302.17},
abstract = {Adrenomedullin (AM) is a novel hypotensive peptide that also exerts powerful anti-inflammatory effects. We recently showed that AM significantly reduces the clinical severity of acetic acid-induced colitis, an experimental model of inflammatory bowel disease (IBD) in rats. In the present study, we examined the effect of AM in two alternative rat models of IBD. We found that 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced megacolon development in the saline-treated group, but AM treatment reduced the macroscopic damage caused by TNBS. In the dextran sulfate sodium (DSS) model, treatment with AM reduced diarrhea and bloody stool scores, but did not reduce body weight. Histological analysis revealed that in both the TNBS and DSS models, colon inflammation was much more severe in the saline-treated group than in the AM-treated group. These findings indicate that the anti-inflammatory properties of AM make it an effective therapeutic agent for the treatment of IBD in rats.},
year = {2015}
}
TY - JOUR T1 - Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease AU - Sayaka Nagata AU - Tomomi Hikosaka AU - Kazuo Kitamura Y1 - 2015/05/06 PY - 2015 N1 - https://doi.org/10.11648/j.ajls.s.2015030302.17 DO - 10.11648/j.ajls.s.2015030302.17 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 39 EP - 42 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.s.2015030302.17 AB - Adrenomedullin (AM) is a novel hypotensive peptide that also exerts powerful anti-inflammatory effects. We recently showed that AM significantly reduces the clinical severity of acetic acid-induced colitis, an experimental model of inflammatory bowel disease (IBD) in rats. In the present study, we examined the effect of AM in two alternative rat models of IBD. We found that 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced megacolon development in the saline-treated group, but AM treatment reduced the macroscopic damage caused by TNBS. In the dextran sulfate sodium (DSS) model, treatment with AM reduced diarrhea and bloody stool scores, but did not reduce body weight. Histological analysis revealed that in both the TNBS and DSS models, colon inflammation was much more severe in the saline-treated group than in the AM-treated group. These findings indicate that the anti-inflammatory properties of AM make it an effective therapeutic agent for the treatment of IBD in rats. VL - 3 IS - 3-2 ER -
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