Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia

Adane Bitew; Mulu Hassen; Tigist Getachew; Surafel Fentaw

doi:doi:10.11648/j.cmr.20160504.12

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Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia

Adane Bitew, Mulu Hassen, Tigist Getachew, Surafel Fentaw

Published in Clinical Medicine Research (Volume 5, Issue 4)

Received: 21 May 2016 Accepted: 31 May 2016 Published: 14 June 2016

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Abstract

Cryptococcal meningitis is a fungal infection that causes significant morbidity and mortality worldwide. However, its incidence in Ethiopia is poorly known. The present study was undertaken to determine cryptococcal meningitis in Ethiopian patients diagnosed to have meningitis. Cerebrospinal fluid was collected from 201 patients with meningitis attending two tertiary hospitals for the isolation and characterization of major bacterial pathogens implicated in causing meningitis. Left over sample of each patient was screened for cryptococal antigen using lateral flow Assay. Of the total number of 201 patients 17 (8.5%) were positive for cryptococcal antigenemia of which 8 (47.1%) were male patients while 9 (52.9%) were female patients. In conclusion a high prevalence of cryptococcal meningitis in the present study urges detection and /or isolation and characterization of the pathogen in patients diagnosed to have meningitis regardless of the immune status. Furthermore, in view of the increasing number of cryptococcal infections, rapid, sensitive, and specific diagnosis of cryptococcal disease has become more important than ever in Ethiopian health institutions.

Published in	Clinical Medicine Research (Volume 5, Issue 4)
DOI	10.11648/j.cmr.20160504.12
Page(s)	73-76
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Cryptococcus, Meningitis, Ethiopia

References

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APA Style

Adane Bitew, Mulu Hassen, Tigist Getachew, Surafel Fentaw. (2016). Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia. Clinical Medicine Research, 5(4), 73-76. https://doi.org/10.11648/j.cmr.20160504.12

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ACS Style

Adane Bitew; Mulu Hassen; Tigist Getachew; Surafel Fentaw. Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia. Clin. Med. Res. 2016, 5(4), 73-76. doi: 10.11648/j.cmr.20160504.12

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AMA Style

Adane Bitew, Mulu Hassen, Tigist Getachew, Surafel Fentaw. Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia. Clin Med Res. 2016;5(4):73-76. doi: 10.11648/j.cmr.20160504.12

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@article{10.11648/j.cmr.20160504.12,
  author = {Adane Bitew and Mulu Hassen and Tigist Getachew and Surafel Fentaw},
  title = {Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia},
  journal = {Clinical Medicine Research},
  volume = {5},
  number = {4},
  pages = {73-76},
  doi = {10.11648/j.cmr.20160504.12},
  url = {https://doi.org/10.11648/j.cmr.20160504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20160504.12},
  abstract = {Cryptococcal meningitis is a fungal infection that causes significant morbidity and mortality worldwide. However, its incidence in Ethiopia is poorly known. The present study was undertaken to determine cryptococcal meningitis in Ethiopian patients diagnosed to have meningitis. Cerebrospinal fluid was collected from 201 patients with meningitis attending two tertiary hospitals for the isolation and characterization of major bacterial pathogens implicated in causing meningitis. Left over sample of each patient was screened for cryptococal antigen using lateral flow Assay. Of the total number of 201 patients 17 (8.5%) were positive for cryptococcal antigenemia of which 8 (47.1%) were male patients while 9 (52.9%) were female patients. In conclusion a high prevalence of cryptococcal meningitis in the present study urges detection and /or isolation and characterization of the pathogen in patients diagnosed to have meningitis regardless of the immune status. Furthermore, in view of the increasing number of cryptococcal infections, rapid, sensitive, and specific diagnosis of cryptococcal disease has become more important than ever in Ethiopian health institutions.},
 year = {2016}
}

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TY  - JOUR
T1  - Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia
AU  - Adane Bitew
AU  - Mulu Hassen
AU  - Tigist Getachew
AU  - Surafel Fentaw
Y1  - 2016/06/14
PY  - 2016
N1  - https://doi.org/10.11648/j.cmr.20160504.12
DO  - 10.11648/j.cmr.20160504.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 73
EP  - 76
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20160504.12
AB  - Cryptococcal meningitis is a fungal infection that causes significant morbidity and mortality worldwide. However, its incidence in Ethiopia is poorly known. The present study was undertaken to determine cryptococcal meningitis in Ethiopian patients diagnosed to have meningitis. Cerebrospinal fluid was collected from 201 patients with meningitis attending two tertiary hospitals for the isolation and characterization of major bacterial pathogens implicated in causing meningitis. Left over sample of each patient was screened for cryptococal antigen using lateral flow Assay. Of the total number of 201 patients 17 (8.5%) were positive for cryptococcal antigenemia of which 8 (47.1%) were male patients while 9 (52.9%) were female patients. In conclusion a high prevalence of cryptococcal meningitis in the present study urges detection and /or isolation and characterization of the pathogen in patients diagnosed to have meningitis regardless of the immune status. Furthermore, in view of the increasing number of cryptococcal infections, rapid, sensitive, and specific diagnosis of cryptococcal disease has become more important than ever in Ethiopian health institutions.
VL  - 5
IS  - 4
ER  -

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Author Information

Adane Bitew

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
Mulu Hassen

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
Tigist Getachew

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
Surafel Fentaw

Department of Clinical Bacteriology and Mycology, Ethiopian Public Health Institute, Addis Ababa, Ethiopia

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Plain Text BibTeX RIS

APA Style

Adane Bitew, Mulu Hassen, Tigist Getachew, Surafel Fentaw. (2016). Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia. Clinical Medicine Research, 5(4), 73-76. https://doi.org/10.11648/j.cmr.20160504.12

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ACS Style

Adane Bitew; Mulu Hassen; Tigist Getachew; Surafel Fentaw. Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia. Clin. Med. Res. 2016, 5(4), 73-76. doi: 10.11648/j.cmr.20160504.12

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AMA Style

Adane Bitew, Mulu Hassen, Tigist Getachew, Surafel Fentaw. Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia. Clin Med Res. 2016;5(4):73-76. doi: 10.11648/j.cmr.20160504.12

Copy | Download

@article{10.11648/j.cmr.20160504.12,
  author = {Adane Bitew and Mulu Hassen and Tigist Getachew and Surafel Fentaw},
  title = {Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia},
  journal = {Clinical Medicine Research},
  volume = {5},
  number = {4},
  pages = {73-76},
  doi = {10.11648/j.cmr.20160504.12},
  url = {https://doi.org/10.11648/j.cmr.20160504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20160504.12},
  abstract = {Cryptococcal meningitis is a fungal infection that causes significant morbidity and mortality worldwide. However, its incidence in Ethiopia is poorly known. The present study was undertaken to determine cryptococcal meningitis in Ethiopian patients diagnosed to have meningitis. Cerebrospinal fluid was collected from 201 patients with meningitis attending two tertiary hospitals for the isolation and characterization of major bacterial pathogens implicated in causing meningitis. Left over sample of each patient was screened for cryptococal antigen using lateral flow Assay. Of the total number of 201 patients 17 (8.5%) were positive for cryptococcal antigenemia of which 8 (47.1%) were male patients while 9 (52.9%) were female patients. In conclusion a high prevalence of cryptococcal meningitis in the present study urges detection and /or isolation and characterization of the pathogen in patients diagnosed to have meningitis regardless of the immune status. Furthermore, in view of the increasing number of cryptococcal infections, rapid, sensitive, and specific diagnosis of cryptococcal disease has become more important than ever in Ethiopian health institutions.},
 year = {2016}
}

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TY  - JOUR
T1  - Prevalence of Crytpococcal Infection in Patients Clinically Diagnosed to Have Meningitis in Ethiopia
AU  - Adane Bitew
AU  - Mulu Hassen
AU  - Tigist Getachew
AU  - Surafel Fentaw
Y1  - 2016/06/14
PY  - 2016
N1  - https://doi.org/10.11648/j.cmr.20160504.12
DO  - 10.11648/j.cmr.20160504.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 73
EP  - 76
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20160504.12
AB  - Cryptococcal meningitis is a fungal infection that causes significant morbidity and mortality worldwide. However, its incidence in Ethiopia is poorly known. The present study was undertaken to determine cryptococcal meningitis in Ethiopian patients diagnosed to have meningitis. Cerebrospinal fluid was collected from 201 patients with meningitis attending two tertiary hospitals for the isolation and characterization of major bacterial pathogens implicated in causing meningitis. Left over sample of each patient was screened for cryptococal antigen using lateral flow Assay. Of the total number of 201 patients 17 (8.5%) were positive for cryptococcal antigenemia of which 8 (47.1%) were male patients while 9 (52.9%) were female patients. In conclusion a high prevalence of cryptococcal meningitis in the present study urges detection and /or isolation and characterization of the pathogen in patients diagnosed to have meningitis regardless of the immune status. Furthermore, in view of the increasing number of cryptococcal infections, rapid, sensitive, and specific diagnosis of cryptococcal disease has become more important than ever in Ethiopian health institutions.
VL  - 5
IS  - 4
ER  -

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