Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier

Bohua Feng; Liufen Peng

doi:doi:10.11648/j.ijbse.20160403.13

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Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier

Bohua Feng, Liufen Peng

Published in International Journal of Biomedical Science and Engineering (Volume 4, Issue 3)

Received: 19 September 2016 Published: 27 September 2016

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Abstract

Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthetised as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.

Published in	International Journal of Biomedical Science and Engineering (Volume 4, Issue 3)
DOI	10.11648/j.ijbse.20160403.13
Page(s)	28-33
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Nanocarrier, Chitosan Derivative, Drug Carrier

References

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[2]	M. A. Elgadir , M. S. Uddin, S. Ferdosh, A. Adam, A. J. K. Chowdhury and M. Z. I. Sarker, “Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: a review,” Journal of Food & Drug Analysis, vol. 23, no. 4, pp. 619-629, 2014.
[3]	B. H. Feng and L. F. Peng, “Synthesis and characterization of carboxymethyl chitosan carrying ricinoleic functions as an emulsifier for azadirachtin,” Carbohydrate Polymers, vol. 88, no. 2, pp. 576–582, 2012.
[4]	D. B. Shenoy and G. B. Sukhorukov. “Engineered microcrystals for direct surface modification with layer-by-layer technique for optimized dissolution,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 58, no.3, pp. 521-527, 2004.
[5]	A. Kamari, N. F. A. Aljafree and S. N. M. Yusoff, “Oleoyl-carboxymethyl chitosan as a new carrier agent for the rotenone pesticide,” Environmental Chemistry Letters, vol. 14, no. 3, pp. 417-422, 2016.
[6]	Y. K. Wu, J. Lin and M.Ye, “Determination of Rotenone by High Performance Liquid Chromatography,” Yunnan Chemical Technology, vol. 33, no. 2, pp. 59-60, 2006.
[7]	X. H. He and F, Schmid, “Spontaneous formation of complex micelles from a homogeneous solution,” Physical review letters, vol. 100, no. 13, pp. 137802. 2007
[8]	F. Bassyouni, N. Elhalwany, M. A. Rehim and M. Neyfeh, “Advances and new technologies applied in controlled drug delivery system,” Research on Chemical Intermediates, vol. 41, no. 4, pp. 1-36, 2013.
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[10]	L. LI, X. Y. Xu and J. P. Zhou, “Preparation and characterization of N-octyl-N'-succinyl chitosan micelles,” Chinese Journal of New Drugs, vol. 16, no. 7, pp. 543-547, 2007.

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APA Style

Bohua Feng, Liufen Peng. (2016). Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. International Journal of Biomedical Science and Engineering, 4(3), 28-33. https://doi.org/10.11648/j.ijbse.20160403.13

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ACS Style

Bohua Feng; Liufen Peng. Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. Int. J. Biomed. Sci. Eng. 2016, 4(3), 28-33. doi: 10.11648/j.ijbse.20160403.13

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AMA Style

Bohua Feng, Liufen Peng. Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. Int J Biomed Sci Eng. 2016;4(3):28-33. doi: 10.11648/j.ijbse.20160403.13

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@article{10.11648/j.ijbse.20160403.13,
  author = {Bohua Feng and Liufen Peng},
  title = {Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {4},
  number = {3},
  pages = {28-33},
  doi = {10.11648/j.ijbse.20160403.13},
  url = {https://doi.org/10.11648/j.ijbse.20160403.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20160403.13},
  abstract = {Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthetised as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.},
 year = {2016}
}

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TY  - JOUR
T1  - Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier
AU  - Bohua Feng
AU  - Liufen Peng
Y1  - 2016/09/27
PY  - 2016
N1  - https://doi.org/10.11648/j.ijbse.20160403.13
DO  - 10.11648/j.ijbse.20160403.13
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 28
EP  - 33
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20160403.13
AB  - Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthetised as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.
VL  - 4
IS  - 3
ER  -

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Author Information

Bohua Feng

College of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou, P. R. China
Liufen Peng

College of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou, P. R. China

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APA Style

Bohua Feng, Liufen Peng. (2016). Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. International Journal of Biomedical Science and Engineering, 4(3), 28-33. https://doi.org/10.11648/j.ijbse.20160403.13

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ACS Style

Bohua Feng; Liufen Peng. Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. Int. J. Biomed. Sci. Eng. 2016, 4(3), 28-33. doi: 10.11648/j.ijbse.20160403.13

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AMA Style

Bohua Feng, Liufen Peng. Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. Int J Biomed Sci Eng. 2016;4(3):28-33. doi: 10.11648/j.ijbse.20160403.13

Copy | Download

@article{10.11648/j.ijbse.20160403.13,
  author = {Bohua Feng and Liufen Peng},
  title = {Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {4},
  number = {3},
  pages = {28-33},
  doi = {10.11648/j.ijbse.20160403.13},
  url = {https://doi.org/10.11648/j.ijbse.20160403.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20160403.13},
  abstract = {Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthetised as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.},
 year = {2016}
}

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TY  - JOUR
T1  - Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier
AU  - Bohua Feng
AU  - Liufen Peng
Y1  - 2016/09/27
PY  - 2016
N1  - https://doi.org/10.11648/j.ijbse.20160403.13
DO  - 10.11648/j.ijbse.20160403.13
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 28
EP  - 33
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20160403.13
AB  - Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthetised as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.
VL  - 4
IS  - 3
ER  -

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